CTP offered a broad survey to advanced topics in web application testing, penetration testing, and exploit development. Evasion Techniques and Breaching Defenses (PEN-300) is a more thorough course focused strictly on penetration testing, and especially avoiding defenses.
The web application security aspect of CTP has been taken over by Advanced Web Attacks and Exploitation (WEB-300). The forthcoming Windows Usermode Exploit Development (EXP-301) course will cover the exploit development portion of CTP.
Of the new courses, Windows Usermode Exploit Development is about exploit development, reverse engineering, and working directly with a debugger. Evasion Techniques and Breaching Defenses focuses on advanced pentesting techniques, largely around bypassing various layers of security.